Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 4/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 8/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076897 | 0.86 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1TDP1KCNH2 | |
| SCHEMBL7269370 | 0.85 | ABCC9 (0.36) | ABCC9KCNE1KCNQ1TDP1KCNH2 | |
| SCHEMBL8085194 | 0.85 | ABCC9 (0.36) | ABCC9 | |
| SCHEMBL8085113 | 0.84 | ABCC9 (0.36) | ABCC9KCNE1KCNQ1TDP1KCNH2 | |
| SCHEMBL7323149 | 0.84 | ABCC9 (0.56) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL7326453 | 0.83 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1TDP1 | |
| SCHEMBL7331673 | 0.82 | ABCC9 (0.39) | ABCC9 | |
| SCHEMBL7332970 | 0.81 | ABCC9 (0.36) | ABCC9KCNE1KCNQ1TDP1 | |
| SCHEMBL7334637 | 0.81 | ABCC9 (0.35) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL7330402 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |