Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.66 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.66 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.66 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.52 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.52 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322966 | 0.83 | ORAI1 (0.76) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL30096576 | 0.80 | ORAI1 (1.00) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7325729 | 0.80 | ORAI1 (1.00) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7327546 | 0.73 | NPC1 (0.41) | ORAI1TRPC3TRPC5TP53 | |
| SCHEMBL7326456 | 0.73 | ORAI1 (0.66) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7325477 | 0.71 | ORAI1 (0.79) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7319538 | 0.71 | ORAI1 (0.79) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7325966 | 0.71 | STIM1 (0.64) | ORAI1TRPC3STIM1TRPC1EPHX2 | |
| SCHEMBL7324706 | 0.71 | ORAI1 (0.71) | ORAI1TRPC3STIM1TRPC1CRACR2A | |
| SCHEMBL7320569 | 0.71 | ORAI1 (0.75) | ORAI1TRPC3STIM1TRPC1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | ORAI1 3522/4885TRPC3 4362/4885STIM1 2302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.