Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.54 |
| ▸ | GNPAT | O15228 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | NPY4R | P50391 | 7/20 | 0.46 |
| ▸ | NPY1R | P25929 | 5/20 | 0.46 |
| ▸ | NPY2R | P49146 | 3/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.46 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321037 | 0.88 | NPY4R (0.58) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL5966616 | 0.87 | GNPAT (0.50) | MMEGNPATACEMMP3CPA1 | |
| SCHEMBL5966623 | 0.87 | GNPAT (0.50) | MMEGNPATACEMMP3CPA1 | |
| SCHEMBL5966704 | 0.87 | GNPAT (0.50) | MMEGNPATACEMMP3CPA1 | |
| SCHEMBL31184527 | 0.85 | NPY4R (0.61) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL10381527 | 0.85 | GNPAT (0.57) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL30692730 | 0.85 | GNPAT (0.57) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL11294449 | 0.85 | GNPAT (0.70) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL29577090 | 0.85 | NPY4R (0.61) | GNPATNPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL4048028 | 0.85 | NPY4R (0.61) | GNPATNPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |