SCHEMBL7325872

SCHEMBL7325872

O=C(S)C(Sc1nc2cc(Cl)ccc2s1)c1ccccc1

nearest known ligand 0.82

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 16/20 0.82
SMN1; SMN2 Q16637 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MEN1 O00255 2/20 0.46
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.46
HPGD P15428 2/20 0.46
KMT2A Q03164 2/20 0.46
KDM4E B2RXH2 1/20 0.46
PSMD14 O00487 1/20 0.46
MMP2 P08253 1/20 0.46
GAA P10253 1/20 0.46
KCNH2 Q12809 1/20 0.46
NPC1 O15118 1/20 0.46
TSHR P16473 1/20 0.46
RAB9A P51151 1/20 0.46
HSD17B10 Q99714 1/20 0.46
ALOX5 P09917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331187 0.90 PPARA (1.00) PPARASMN1; SMN2NPSR1MEN1ALDH1A1
SCHEMBL7324266 0.88 PPARA (0.82) PPARASMN1; SMN2NPSR1MEN1ALDH1A1
SCHEMBL2837046 0.86 PPARA (0.79) PPARAMEN1MAPTKMT2AALOX5
SCHEMBL7325879 0.85 PPARA (0.78) PPARASMN1; SMN2NPSR1MEN1ALDH1A1
SCHEMBL7321487 0.85 PPARA (0.77) PPARAMEN1MAPTKMT2A
SCHEMBL7325252 0.84 PPARA (0.88) PPARASMN1; SMN2NPSR1ALOX5
SCHEMBL11386756 0.83 PPARA (0.74) PPARAALOX5
SCHEMBL7331473 0.82 PPARA (0.72) PPARAALOX5
SCHEMBL7331454 0.82 PPARA (0.72) PPARAALOX5
SCHEMBL7334028 0.82 PPARA (0.71) PPARAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0067685-B1 ALPHA-PHENYL-2-(AZA)BENZOTHIAZOLYLTHIOGLYCOLIC ACIDS AND DERIVATIVES THEREOF AMERICAN HOME PRODUCTS CORPORATION (US) 1986-11-05 EP claimed
EP-0067685-B1 ALPHA-PHENYL-2-(AZA)BENZOTHIAZOLYLTHIOGLYCOLIC ACIDS AND DERIVATIVES THEREOF AMERICAN HOME PRODUCTS CORPORATION (US) 1986-11-05 EP disclosed
US-4567267-A α-Phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof AMERICAN HOME PRODUCTS CORPORATION (US) 1986-01-28 US disclosed
US-4367233-A ALPHA-PHENYL-2-/AZA/BENZOTHIAZOYLTHIOGLYCOLIC ACIDS AMERICAN HOME PRODUCTS CORPORATION (US) 1983-01-04 US disclosed