Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 5/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325940 | 0.92 | CAPN1 (0.60) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL7324809 | 0.88 | CTSL (0.55) | CAPN1CTSLCTSSCTSKF2 | |
| SCHEMBL7322013 | 0.87 | CAPN1 (0.55) | CAPN1HDAC8CTSLCTSSCTSK | |
| SCHEMBL7325391 | 0.87 | CAPN1 (0.56) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL7326939 | 0.86 | CTSL (0.56) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL7324287 | 0.85 | CAPN1 (0.53) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL7321072 | 0.85 | CAPN1 (0.55) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL7321107 | 0.84 | TACR1 (0.51) | CAPN1CTSLCTSSCTSKF2 | |
| SCHEMBL10967811 | 0.84 | CAPN1 (0.72) | CAPN1CTSLCTSSCTSKTACR1 | |
| SCHEMBL31397615 | 0.84 | CAPN1 (0.72) | CAPN1CTSLCTSSCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |