Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13407665 | 0.88 | KDR (0.61) | FGFR3KDRFLT3 | |
| SCHEMBL3581751 | 0.86 | FGFR3 (0.61) | FGFR3KDRPKMCDK2FLT3 | |
| SCHEMBL3590921 | 0.86 | FGFR3 (0.56) | FGFR3KDRCDK2FLT3 | |
| Hydrochloric Acid SCHEMBL17157044 | 0.85 | FGFR3 (0.55) | FGFR3KDRCDK2FLT3 | |
| SCHEMBL13407683 | 0.83 | FGFR3 (0.60) | FGFR3KDR | |
| SCHEMBL73095 | 0.83 | PKM (0.53) | FGFR3KDRPKMCDK2CDK1 | |
| SCHEMBL563607 | 0.82 | FGFR3 (0.62) | FGFR3KDR | |
| SCHEMBL3590287 | 0.82 | KDR (0.63) | FGFR3KDRFLT3 | |
| Hydrochloric Acid SCHEMBL17157041 | 0.82 | FGFR3 (0.59) | FGFR3KDR | |
| SCHEMBL2911187 | 0.82 | FGFR3 (0.59) | FGFR3KDRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |