Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31210678 | 0.84 | KDM4E (0.49) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL7354451 | 0.84 | KDM4E (0.49) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL23534393 | 0.81 | KDM4E (0.46) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL7319485 | 0.80 | SMN1; SMN2 (0.39) | KDM4EPOLBALDH1A1GAACYP1A2 | |
| SCHEMBL13764178 | 0.80 | KDM4E (0.54) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL29772651 | 0.79 | KDM4E (0.36) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL25397343 | 0.76 | MAPK1 (0.50) | KDM4EPOLBALDH1A1HPGDCYP1A2 | |
| SCHEMBL31210467 | 0.76 | KDM4E (0.49) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL5554280 | 0.76 | KMT2A (0.49) | KDM4EPOLBALDH1A1HPGDGAA | |
| SCHEMBL29772664 | 0.76 | MERTK (0.39) | KDM4EPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028605-A | Antispasmodic, bronchodilators, uterine relaxants, cardiac analeptics, neurosedatives | L'UNIVERSITE DE MONTPELLIER I (FR) | 1991-07-02 | — | — | US | disclosed |
| EP-0348392-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Université Montpellier I (FR) | 1990-01-03 | — | — | EP | disclosed |
| WO-1988004298-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1988-06-16 | — | — | WO | disclosed |