Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.67 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.67 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.67 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315607 | 0.93 | ORAI1 (0.62) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7321270 | 0.92 | ORAI1 (0.66) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7327901 | 0.91 | ORAI1 (0.67) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL14887701 | 0.90 | ORAI1 (0.75) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7326083 | 0.90 | CRACR2A (0.57) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7325983 | 0.88 | ORAI1 (0.67) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7327861 | 0.88 | ORAI1 (0.69) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7326834 | 0.87 | ORAI1 (0.75) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL14887703 | 0.87 | CRACR2A (0.57) | ORAI1TRPC3TRPC1STIM1TP53 | |
| SCHEMBL7325653 | 0.86 | MAPT (0.71) | ORAI1TRPC3TRPC1STIM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | claimed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ORAI1 1/4885TRPC3 39/4885TRPC1 34/4885 |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | ORAI1 3522/4885TRPC3 4362/4885TRPC1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.