Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328970 | 0.86 | ABCC9 (0.42) | ABCC9ABCB1KDM4E | |
| SCHEMBL7324552 | 0.86 | ABCC9 (0.40) | ABCC9ABCB1KDM4E | |
| SCHEMBL7332374 | 0.86 | ABCB1 (0.39) | ABCC9ABCB1KDM4E | |
| SCHEMBL7324385 | 0.84 | ABCC9 (0.38) | ABCC9ABCB1KDM4E | |
| SCHEMBL7326444 | 0.83 | ABCC9 (0.39) | ABCC9ABCB1KDM4ECYP3A4ALOX15 | |
| SCHEMBL7323624 | 0.83 | ABCC9 (0.40) | ABCC9ABCB1KDM4E | |
| SCHEMBL7331068 | 0.82 | ABCB1 (0.38) | ABCC9ABCB1KDM4E | |
| SCHEMBL7326400 | 0.81 | ABCC9 (0.43) | ABCC9ABCB1KDM4E | |
| SCHEMBL7325525 | 0.81 | ABCB1 (0.39) | ABCC9ABCB1KDM4E | |
| SCHEMBL7273801 | 0.81 | ABCC9 (0.39) | ABCC9ABCB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0340718-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |