Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 8/20 | 0.38 |
| ▸ | METAP1 | P53582 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435879 | 1.00 | REN (0.41) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7340194 | 0.89 | REN (0.40) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7278123 | 0.89 | REN (0.40) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7436405 | 0.89 | REN (0.42) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL9442976 | 0.86 | REN (0.39) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL9832192 | 0.86 | REN (0.39) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL5671311 | 0.81 | REN (0.40) | RENMETAP2METAP1CYP1A2 | |
| SCHEMBL5670653 | 0.79 | REN (0.38) | RENMETAP2METAP1 | |
| SCHEMBL9831980 | 0.77 | REN (0.37) | RENMETAP2METAP1 | |
| SCHEMBL10610858 | 0.77 | REN (0.37) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |