Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.70 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.67 |
| ▸ | CTSL | P07711 | 7/20 | 0.66 |
| ▸ | CTSB | P07858 | 4/20 | 0.66 |
| ▸ | CTSS | P25774 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872585 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL14148467 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL2930262 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL8823918 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL7318823 | 0.95 | CTSK (0.69) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL25406813 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL20770085 | 0.95 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL7325036 | 0.94 | CAPN1 (0.72) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL8585293 | 0.92 | CAPN1 (0.72) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL7326839 | 0.91 | CTSK (0.67) | CTSKCAPN1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | claimed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | claimed |
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | disclosed |
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |