Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429870 | 0.81 | PDE3B (0.39) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL9430321 | 0.80 | XDH (0.39) | MAPTADORA2BXDHALDH1A1CYP3A4 | |
| SCHEMBL31438586 | 0.78 | MAPT (0.48) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL541696 | 0.77 | MAPT (0.42) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL1111557 | 0.77 | MAPT (0.36) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL1150739 | 0.75 | XDH (0.47) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL3399435 | 0.74 | MAPT (0.48) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL6347021 | 0.74 | MAPT (0.53) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL9386889 | 0.73 | MAPT (0.44) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL3423321 | 0.73 | MAPT (0.44) | MAPTADORA2BXDHGDAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485495-A1 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | Beecham Group p.l.c. (GB) | 1992-05-20 | — | — | EP | disclosed |
| WO-1991001730-A2 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | BEECHAM GROUP PLC (GB) | 1991-02-21 | — | — | WO | disclosed |
| EP-0260127-A2 | Xanthine derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-03-16 | — | — | EP | disclosed |