Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7331885 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7327010 | 0.92 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7326401 | 0.89 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7326394 | 0.89 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7328287 | 0.89 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7326067 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7331894 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7324768 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7327894 | 0.88 | BRD4 (0.47) | SMN1; SMN2MAPK1MEN1KMT2AALDH1A1 | |
| Fumaric Acid SCHEMBL7331898 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | claimed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | claimed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | claimed |