Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PPIA | P62937 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327902 | 0.92 | BRD4 (0.47) | BRD4POLBL3MBTL1TDP1GAA | |
| SCHEMBL7327002 | 0.88 | SMN1; SMN2 (0.53) | POLBGAATSHRSMN1; SMN2MAPK1 | |
| SCHEMBL7326394 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7328287 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7326401 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| Fumaric Acid SCHEMBL7331885 | 0.85 | SMN1; SMN2 (0.48) | POLBGAATSHRSMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL7324768 | 0.85 | SMN1; SMN2 (0.54) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7331894 | 0.85 | SMN1; SMN2 (0.54) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7326067 | 0.85 | SMN1; SMN2 (0.54) | L3MBTL1TSHRSMN1; SMN2MEN1ALDH1A1 | |
| Fumaric Acid SCHEMBL9617092 | 0.83 | GAA (0.38) | POLBGAAPKMTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |