Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 2/20 | 0.42 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733295 | 0.87 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL734302 | 0.87 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733947 | 0.85 | PIK3CD (0.59) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733231 | 0.84 | PIK3CD (0.58) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733199 | 0.83 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733067 | 0.81 | PIK3CD (0.60) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733097 | 0.81 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL733839 | 0.81 | PIK3CD (0.75) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL1426323 | 0.79 | PIK3CD (0.58) | PIK3CDPIK3R1PIK3CBPIK3CGPI4KA | |
| SCHEMBL734208 | 0.78 | PIK3CD (0.88) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | claimed |