Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730949 | 0.71 | KDM4E (0.53) | ALDH1A1SMN1; SMN2NPSR1KDM4ENPC1 | |
| SCHEMBL733114 | 0.71 | CA12 (0.40) | ALDH1A1TP53TSHRLMNAMEN1 | |
| SCHEMBL730915 | 0.70 | KDM4E (0.38) | ALDH1A1TP53SIRT2SIRT1SMN1; SMN2 | |
| SCHEMBL3510581 | 0.70 | KDM4E (0.55) | ALDH1A1SMN1; SMN2NPSR1KDM4ENPC1 | |
| SCHEMBL742211 | 0.69 | KDM4E (0.39) | ALDH1A1TP53SIRT2SIRT1SMN1; SMN2 | |
| SCHEMBL732746 | 0.69 | NPC1 (0.37) | ALDH1A1SIRT2SIRT1SMN1; SMN2NPSR1 | |
| SCHEMBL21817920 | 0.69 | KDM4E (0.45) | ALDH1A1SMN1; SMN2NPSR1KDM4ENPC1 | |
| SCHEMBL357782 | 0.68 | ALDH1A1 (0.53) | ALDH1A1TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2276958 | 0.68 | NOTUM (0.49) | ALDH1A1TP53SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL731026 | 0.68 | KDM4E (0.40) | ALDH1A1SMN1; SMN2NPSR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | ALDH1A1 113/4885TP53 2365/4885SIRT2 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.