Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 8/20 | 0.74 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.64 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.64 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.64 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883639 | 0.85 | CRACR2A (1.00) | CRACR2AORAI1TP53THRBNPC1 | |
| SCHEMBL7234017 | 0.82 | TP53 (0.86) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7240068 | 0.81 | CRACR2A (0.74) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL4120694 | 0.81 | ORAI1 (0.64) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7325947 | 0.81 | ORAI1 (0.64) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7328795 | 0.80 | TP53 (0.69) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7326340 | 0.79 | ORAI1 (0.73) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7325708 | 0.79 | ORAI1 (0.79) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7327208 | 0.78 | ORAI1 (0.64) | CRACR2AORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7319568 | 0.78 | ORAI1 (0.64) | CRACR2AORAI1TRPC3TRPC1STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | CRACR2A 3286/4885ORAI1 3522/4885TRPC3 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.