Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.54 |
| ▸ | FNTB | P49356 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.32 |
| ▸ | PPARD | Q03181 | 5/20 | 0.32 |
| ▸ | PPARA | Q07869 | 5/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555677 | 0.87 | FNTA (0.68) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| SCHEMBL555674 | 0.87 | FNTA (0.68) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| SCHEMBL166087 | 0.87 | FNTA (0.68) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| SCHEMBL1300976 | 0.83 | FNTA (0.52) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| SCHEMBL17010800 | 0.80 | ALDH1A1 (0.50) | FNTAFNTBTHRBPGGT1BALDH1A1 | |
| SCHEMBL6695771 | 0.80 | FNTA (0.43) | FNTAFNTBTHRBPGGT1BALDH1A1 | |
| SCHEMBL2547697 | 0.79 | FNTA (0.46) | FNTAFNTBTHRBPGGT1BFFAR3 | |
| SCHEMBL2122443 | 0.78 | FNTA (0.47) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| SCHEMBL25269291 | 0.76 | CES1 (0.45) | FNTAFNTBTHRBPGGT1BHDAC3 | |
| Pyruvate SCHEMBL11244266 | 0.76 | FFAR3 (0.77) | HDAC3HDAC1HDAC2HDAC8FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658211-B2 | Polyconjugates for in vivo delivery of polynucleotides | Arrowhead Madison Inc. (US) | 2014-02-25 | — | — | US | disclosed |
| US-8658211-B2 | Polyconjugates for in vivo delivery of polynucleotides | Arrowhead Madison Inc. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20120230938-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | Arrowhead Madison Inc. (US) | 2012-09-13 | — | — | US | disclosed |
| US-8137695-B2 | Transferring interfering RNA sequences into cells via conjugation with physiologically labile bond associated with polyamine and/or polyvinyl ether | Arrowhead Madison Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138383-B2 | For cellular delivery; heterogeneity polymer containing cationic groups and hydrophobic groups | Arrowhead Madison Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8017109-B2 | Cellular deivery, random polyacrylate with multiple hydrophobic monomer | ROCHE MADISON INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-8008355-B2 | Delivering nucleic acids to cells; copolymer containing amine monomer and hydrophobic segments | ROCHE MADISON INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-7985406-B2 | For cellular delivery; heteropolymer containing amine containing monomer and hydrophobic monomers | ROCHE MADISON INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090048410-A1 | Membrane Active Heteropolymers | Arrowhead Pharmaceuticals, Inc. | 2009-02-19 | — | — | US | disclosed |
| US-20090023890-A1 | Membrane Active Heteropolymers | Arrowhead Pharmaceuticals, Inc. | 2009-01-22 | — | — | US | disclosed |
| US-20080287630-A1 | Endosomolytic Poly(Acrylate) Polymers | Arrowhead Pharmaceuticals, Inc. | 2008-11-20 | — | — | US | disclosed |
| US-20080287628-A1 | Endosomolytic Poly(Vinyl Ether) Polymers | Arrowhead Madison Inc. | 2008-11-20 | — | — | US | disclosed |
| US-20080281044-A1 | Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers | ROCHE MADISON INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080281041-A1 | Reverse deactivation of membrane active polymers; cell delivery; labile bonding of polyamines, polyvinyl alcohol, polyallylamine or polyoxyethylene glycol | Arrowhead Madison Inc. | 2008-11-13 | — | — | US | disclosed |
| US-20080269450-A1 | Endosomolytic Poly-Beta-Aminoester Polymers | ROCHE MADISON INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080152661-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | Arrowhead Pharmaceuticals, Inc. | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120230938-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | PHAX, NCL, PCBP1 | FNTA 1870/4885FNTB 1247/4885THRB 3188/4885 |
| US-20080152661-A1 | Polyconjugates for In Vivo Delivery of Polynucleotides | PHAX, PCBP1, NCL | FNTA 1771/4885FNTB 1176/4885THRB 3332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.