Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.72 |
| ▸ | HTR7 | P34969 | 3/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8403779 | 0.99 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9726195 | 0.92 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL14318600 | 0.91 | HTR2A (0.81) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL11516583 | 0.90 | HTR2A (0.70) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL8714691 | 0.87 | HTR2A (0.74) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL11747892 | 0.87 | KCNH2 (0.64) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL10928970 | 0.85 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9229261 | 0.85 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL10928975 | 0.85 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL20577435 | 0.85 | HTR2A (0.71) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841330-B1 | Aminomethyl heterocyclic derivatives, process of their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-27 | — | — | EP | disclosed |
| US-5919784-A | ANXIETY, DEPRESSION | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0841330-A1 | Aminomethyl heterocyclic derivatives, process of their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-05-13 | — | — | EP | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |
| US-5077288-A | Adrenergic, serotonin and histamine antagonist | ADIR ET COMPAGNIE (FR) | 1991-12-31 | — | — | US | disclosed |
| US-4151285-A | ANTICONVULSANT, ANTI-ANXIETY AGENTS | A. H. ROBINS COMPANY, INC. (US) | 1979-04-24 | — | — | US | disclosed |
| US-4032642-A | SEDATIVES, TRANQUILIZERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1977-06-28 | — | — | US | disclosed |
| US-3956296-A | ANTIINFLAMMATORY, SEDATIVES, TRANQUILIZERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-05-11 | — | — | US | disclosed |