Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.72 |
| ▸ | HTR7 | P34969 | 3/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10577348 | 0.99 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| Hydrochloric Acid SCHEMBL10712477 | 0.99 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9396999 | 0.92 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL14318600 | 0.91 | HTR2A (0.81) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL228454 | 0.90 | HTR2A (0.70) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9534623 | 0.89 | HTR2A (0.68) | HTR2AHTR2CHTR7HTR6KDM4E | |
| Hydrochloric Acid SCHEMBL9869610 | 0.88 | HTR2A (0.67) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL8714691 | 0.87 | HTR2A (0.74) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL10928970 | 0.85 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL10928975 | 0.85 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314444-B1 | Novel oxathiolanes and derivatives thereof, pharmaceutical compositions containing them and the use thereof as medicaments | ISRAEL STATE (IL) | 1996-05-29 | — | — | EP | claimed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |
| EP-0377528-B1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA (FR) | 1993-12-08 | — | — | EP | disclosed |
| EP-0316668-B1 | USE OF A TETRAHYDRO-PYRIDO(2,3-D)PYRIMIDINE FOR OBTAINING AN ANALGETIC AGENT | MERCK PATENT GmbH (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0184258-B1 | NOVEL DERIVATIVES OF HYDROXY- OR AMINO-SUBSTITUTED (PIPERIDINYLALKYL)QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-05-06 | — | — | EP | disclosed |
| US-5001134-A | Piperidines, processes of preparation and medications containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1991-03-19 | — | — | US | disclosed |
| US-4950648-A | SUBSTITUTED PYRIDO(2,3-D) OR PYRIMIDO(4,5-D) PYRIMIDINE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-08-21 | — | — | US | disclosed |
| EP-0377528-A1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-07-11 | — | — | EP | disclosed |
| EP-0316668-A2 | Use of a tetrahydro-pyrido(2,3-d)pyrimidine for obtaining an analgetic agent | MERCK PATENT GmbH (DE) | 1989-05-24 | — | — | EP | disclosed |
| US-4665075-A | ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-05-12 | — | — | US | disclosed |
| EP-0184258-A2 | Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-06-11 | — | — | EP | disclosed |