Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 12/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7329715 | 0.99 | GRIN2B (0.69) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| SCHEMBL7329677 | 0.99 | GRIN2B (0.69) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7337819 | 0.98 | GRIN2B (0.67) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7333173 | 0.98 | GRIN2B (0.67) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7334760 | 0.98 | GRIN2B (0.67) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7326858 | 0.98 | GRIN2B (0.67) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7329362 | 0.98 | GRIN2B (0.67) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| SCHEMBL7325905 | 0.96 | GRIN2B (0.70) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7336883 | 0.95 | GRIN2B (0.68) | GRIN2BSIGMAR1GRIN1DRD2DRD3 | |
| SCHEMBL7328462 | 0.91 | GRIN2B (0.68) | GRIN2BSIGMAR1GRIN1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | claimed |
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |