SCHEMBL7328294

SCHEMBL7328294

CCCCCCNS(=O)(=O)c1cccc2c(CC(C)=O)nccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.58
CYP1A2 P05177 6/20 0.58
CYP2C19 P33261 6/20 0.58
TP53 P04637 5/20 0.58
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
TSHR P16473 3/20 0.58
TDP1 Q9NUW8 3/20 0.58
CA12 O43570 2/20 0.48
CA9 Q16790 2/20 0.48
RECQL P46063 1/20 0.47
HDAC4 P56524 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 3/20 0.44
HSD17B10 Q99714 2/20 0.44
HPGD P15428 1/20 0.44
CYP2C9 P11712 5/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7326649 0.82 CYP3A4 (0.54) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL2910538 0.77 CYP3A4 (0.56) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL7319325 0.77 CYP3A4 (0.45) CYP3A4CYP1A2CYP2C19TP53MEN1
Hydrochloric Acid SCHEMBL9832193 0.76 CYP3A4 (0.55) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL2910483 0.75 CYP3A4 (0.62) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL29653788 0.74 CYP3A4 (1.00) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL317323 0.74 CYP3A4 (1.00) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL29141930 0.73 CYP3A4 (0.74) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL2937044 0.72 ALOX15 (0.51) CYP3A4CYP1A2CYP2C19TP53MEN1
SCHEMBL13788912 0.72 CYP3A4 (0.69) CYP3A4CYP1A2CYP2C19TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287696-B1 ISOQUINOLINE DERIVATIVES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-01-02 EP disclosed
EP-0287696-A1 Isoquinoline derivatives Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1988-10-26 EP disclosed