Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | YAP1 | P46937 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337139 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2BCL2TAOK1 | |
| SCHEMBL8650717 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2BCL2TAOK1 | |
| SCHEMBL8654091 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2BCL2TAOK1 | |
| SCHEMBL7329129 | 0.91 | KMT2A (0.46) | KMT2AEPHX2PPARAL3MBTL1MAOB | |
| SCHEMBL8652209 | 0.91 | KMT2A (0.46) | KMT2AEPHX2PPARAL3MBTL1MAOB | |
| SCHEMBL7396204 | 0.89 | NPY5R (0.40) | TAOK1KMT2AEPHX2TAOK3L3MBTL1 | |
| SCHEMBL8651847 | 0.89 | NPY5R (0.40) | TAOK1KMT2AEPHX2TAOK3L3MBTL1 | |
| SCHEMBL7327712 | 0.89 | PPARA (0.46) | KMT2AEPHX2PPARAL3MBTL1PPARG | |
| SCHEMBL7328072 | 0.89 | PPARA (0.46) | KMT2AEPHX2PPARAL3MBTL1PPARG | |
| SCHEMBL7335350 | 0.89 | PPARA (0.46) | KMT2AEPHX2PPARAL3MBTL1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711271-B1 | AMINOINDANES AND RELATED COMPOUNDS USEFUL AS CALCIUM-CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-07 | — | — | EP | disclosed |
| EP-0711271-A1 | AMINOINDANES AND RELATED COMPOUNDS USEFUL AS CALCIUM-CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004027-A1 | AMINOINDANES AND RELATED COMPOUNDS USEFUL AS CALCIUM-CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |