SCHEMBL7328486

SCHEMBL7328486

Cc1ccc(N(C)C=O)c([N+](=O)[O-])c1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.55
CYP3A4 P08684 1/20 0.55
ALDH3A1 P30838 2/20 0.44
MCOLN3 Q8TDD5 2/20 0.44
POLB P06746 1/20 0.44
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 2/20 0.43
HTT P42858 1/20 0.43
HCAR3 P49019 1/20 0.43
GPR35 Q9HC97 1/20 0.42
GAA P10253 1/20 0.41
MAPT P10636 3/20 0.40
KAT2B Q92831 2/20 0.39
MAPK1 P28482 1/20 0.39
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2036709 0.82 TSHR (0.62) TSHRCYP3A4MCOLN3POLBALDH1A1
SCHEMBL6230517 0.77 HSD17B10 (0.47) TSHRPOLBALDH1A1GPR35MAPT
SCHEMBL4554976 0.77 TSHR (0.60) TSHRCYP3A4MCOLN3POLBALDH1A1
SCHEMBL29320803 0.77 TSHR (0.55) TSHRCYP3A4ALDH3A1MCOLN3POLB
SCHEMBL6142518 0.75 TDP1 (0.43) TSHRCYP3A4ALDH3A1ALDH1A1KDM4E
SCHEMBL10866707 0.74 CYP3A4 (0.40) CYP3A4ALDH1A1KDM4EHTTGAA
SCHEMBL11613863 0.74 TSHR (0.51) TSHRCYP3A4MCOLN3POLBALDH1A1
SCHEMBL10936850 0.73 TSHR (0.55) TSHRCYP3A4MCOLN3POLBALDH1A1
Hydrochloric Acid SCHEMBL31534634 0.73 CYP3A4 (0.39) CYP3A4ALDH1A1KDM4EHTTGAA
SCHEMBL18676266 0.72 ALDH1A1 (0.55) TSHRCYP3A4ALDH3A1MCOLN3POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1027536-C Process for producing 4,5,6,7-tetrahydrobenzimidazole derivatives YAMANOUCHI PHARMA CO LTD (JP) 1995-02-01 CN disclosed
EP-0376624-B1 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation YAMANOUCHI PHARMA CO LTD (JP) 1994-09-14 EP disclosed
US-4977175-A GASTROINTESTINAL DISORDERS, ANTIEMETICS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1990-12-11 US disclosed
CN-1043706-A 4,5,6,7-tetrahydrobenzene benzimidazole derivative preparation method YAMANOUCHI PHARMA CO LTD (JP) 1990-07-11 CN disclosed
EP-0376624-A1 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1990-07-04 EP disclosed