SCHEMBL7328489

SCHEMBL7328489

CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NC(CC(=O)O)C(=O)COc1ccccc1)C(C)C

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 2/20 0.58
CASP3 P42574 4/20 0.55
BACE1 P56817 3/20 0.55
BACE2 Q9Y5Z0 3/20 0.55
CASP6 P55212 1/20 0.55
CASP8 Q14790 1/20 0.55
OPRD1 P41143 3/20 0.52
CASP7 P55210 1/20 0.49
REN P00797 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18087495 0.86 CASP1 (0.63) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL24310825 0.86 CASP1 (0.63) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL19970821 0.86 CASP1 (0.63) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL29932500 0.86 CASP1 (0.63) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL14369991 0.85 CASP1 (0.54) CASP1CASP3BACE1BACE2CASP6
SCHEMBL12522504 0.85 CASP1 (0.54) CASP1CASP3BACE1BACE2CASP6
SCHEMBL949558 0.85 CASP1 (0.54) CASP1CASP3BACE1BACE2CASP6
SCHEMBL9241543 0.85 CASP1 (0.67) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL27825824 0.85 CASP1 (0.67) CASP1CASP3BACE1BACE2OPRD1
SCHEMBL7277216 0.84 BACE1 (0.58) CASP1CASP3BACE1BACE2OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5866545-A ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS; UROGENITAL DISORDERS MERCK & CO., INC. (US) 1999-02-02 US claimed
US-5866545-A ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS; UROGENITAL DISORDERS MERCK & CO., INC. (US) 1999-02-02 US disclosed
WO-1995005192-A1 SUBSTITUTED KETONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME MERCK & CO., INC. (US) 1995-02-23 WO disclosed