Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207322 | 0.98 | HTR1A (0.50) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL11743490 | 0.69 | HTR1A (0.42) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL7332894 | 0.68 | HTR1A (0.44) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL9719278 | 0.68 | HTR1A (0.44) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL544018 | 0.66 | HTR1A (0.36) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL7328915 | 0.65 | HTR1A (0.38) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL7327343 | 0.64 | HTR1A (0.37) | HTR1APABPC1EIF4HCTDSP1HTT | |
| SCHEMBL11611860 | 0.64 | SLC6A2 (0.41) | HTR1APABPC1EIF4HCTDSP1SLC6A2 | |
| Methane SCHEMBL12474245 | 0.64 | HTR1A (0.42) | HTR1APABPC1EIF4HCTDSP1SLC6A2 | |
| SCHEMBL11715161 | 0.62 | SLC6A2 (0.82) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198433-A | Hypotensive | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5158945-A | Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0370320-B1 | LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-30 | — | — | EP | disclosed |
| US-5128337-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5082837-A | Hypotensive | MERRELL DOW PHARMACEUTICALS (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010072-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0370320-A1 | Lactamimides in the treatment of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-30 | — | — | EP | disclosed |
| US-4061746-A | Lactamimide inhibitors of gastrointestinal hypersecretion | RICHARDSON-MERRELL INC. (US) | 1977-12-06 | — | — | US | disclosed |