Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HTRA2 | O43464 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328626 | 1.00 | MAPT (0.56) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11252888 | 0.87 | PDE4A (0.63) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11710905 | 0.87 | PDE4A (0.63) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11252892 | 0.87 | PDE4A (0.63) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL1116276 | 0.82 | HTRA2 (0.56) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL7330422 | 0.81 | KDM4E (0.52) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL7330415 | 0.81 | KDM4E (0.52) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11778975 | 0.77 | SMN1; SMN2 (0.63) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11778979 | 0.77 | SMN1; SMN2 (0.63) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL13497043 | 0.75 | MAPT (0.67) | MAPTKDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |