Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16054397 | 0.86 | KDM4E (0.62) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL490401 | 0.86 | FFAR1 (0.56) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL28012705 | 0.86 | AKR1B1 (0.49) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL16054136 | 0.84 | F2RL1 (0.54) | F2RL1ALOX5AKR1B1NFKB1NFKB2 | |
| SCHEMBL13574164 | 0.84 | F2RL1 (0.46) | F2RL1ALOX5AKR1B1NFKB1NFKB2 | |
| SCHEMBL2338537 | 0.84 | AKR1B1 (0.47) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL28397070 | 0.84 | AKR1B1 (0.47) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL5884605 | 0.84 | KMT2A (0.51) | F2RL1AKR1B1NFKB1NFKB2RELA | |
| SCHEMBL7332474 | 0.81 | TAAR1 (0.61) | F2RL1RAB9A | |
| SCHEMBL11422604 | 0.81 | HDAC1 (0.56) | HSD17B1HSD17B2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| US-4647446-A | Rapid brain scanning radiopharmaceutical | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1987-03-03 | — | — | US | disclosed |