Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 0.63 |
| ▸ | MME | P08473 | 10/20 | 0.63 |
| ▸ | F2 | P00734 | 2/20 | 0.62 |
| ▸ | PLAU | P00749 | 2/20 | 0.62 |
| ▸ | PLAT | P00750 | 2/20 | 0.62 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.60 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.59 |
| ▸ | PLG | P00747 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334539 | 1.00 | ECE1 (0.63) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL2242657 | 0.89 | F2 (0.55) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL7291199 | 0.89 | ECE1 (0.61) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL2249423 | 0.88 | F2 (0.77) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL15397886 | 0.87 | ACE2 (0.56) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL14334693 | 0.87 | F2 (0.56) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL7397375 | 0.86 | ECE1 (0.59) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL2244756 | 0.86 | F2 (0.59) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL15397862 | 0.86 | ACE2 (0.71) | ECE1MMEACE2 | |
| SCHEMBL7397171 | 0.85 | F2 (0.69) | ECE1MMEF2PLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2676962-A1 | Derivatives of 1-aminoalkylphosphonate diaryl esters, method of 1-aminoalkylphosphonate diaryl ester derivatives preparation and their application | Universität Ulm (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |
| US-4849414-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0249445-A2 | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-12-16 | — | — | EP | disclosed |
| EP-0245942-A2 | Process for preparing phosphonic acids | E.R. Squibb & Sons, Inc. (US) | 1987-11-19 | — | — | EP | disclosed |
| US-4670193-A | OXIDATION | E. R. SQUIBB & SONS, INC. (US) | 1987-06-02 | — | — | US | disclosed |