Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328742 | 1.00 | TSHR (0.64) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL9442990 | 0.98 | TSHR (0.61) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL10447907 | 0.98 | TSHR (0.61) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL9442942 | 0.95 | TSHR (0.57) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL27630758 | 0.85 | TSHR (0.66) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL18390254 | 0.84 | HSD17B10 (0.73) | CHRM1HSD17B10NPC1 | |
| SCHEMBL5479757 | 0.84 | MMP8 (0.64) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL2162836 | 0.84 | MMP8 (0.64) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL2162843 | 0.84 | MMP8 (0.64) | TSHRHPGDGAACHRM1MEN1 | |
| SCHEMBL8077871 | 0.82 | HDAC8 (0.68) | TSHRHPGDGAADPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |