Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371953 | 0.93 | BCL2 (0.40) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL731762 | 0.88 | ALDH1A1 (0.41) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL1414982 | 0.85 | ALDH1A1 (0.41) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL11981019 | 0.85 | ABCB1 (0.42) | MAPTKDM4EPOLBGAARECQL | |
| SCHEMBL4575458 | 0.84 | KDM4E (0.47) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL1415038 | 0.83 | PPARG (0.38) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL30598448 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL4574807 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTCYP3A4USP2LMNA | |
| SCHEMBL12810277 | 0.81 | AKT1 (0.39) | ALDH1A1MAPTCYP3A4KDM4EMEN1 | |
| SCHEMBL1414956 | 0.81 | KDM1A (0.41) | ALDH1A1MAPTKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | claimed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | claimed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | claimed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | claimed |
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | disclosed |
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | disclosed |
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | disclosed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | disclosed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | disclosed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | disclosed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | disclosed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | disclosed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | disclosed |
| EP-2107055-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2011-03-16 | — | — | EP | disclosed |
| WO-2009133269-A1 | NOVEL DIOMESTINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-11-05 | — | — | WO | disclosed |
| EP-2107055-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-10-07 | — | — | EP | disclosed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EDF1, EDNRA, EDNRB | ALDH1A1 991/4885MAPT 4312/4885CYP3A4 307/4885 |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | EDF1, EDNRA, EDNRB | ALDH1A1 1020/4885MAPT 4264/4885CYP3A4 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.