Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.59 |
| ▸ | DRD3 | P35462 | 9/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD5 | P21918 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7336044 | 0.87 | DRD2 (0.61) | DRD2DRD3DRD4HTR1AHTR7 | |
| SCHEMBL7330393 | 0.86 | DRD2 (0.64) | DRD2DRD3DRD4HTR1AHTR7 | |
| SCHEMBL7329114 | 0.85 | DRD2 (0.62) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7331395 | 0.85 | DRD2 (0.62) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7328457 | 0.85 | DRD2 (0.62) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7325770 | 0.85 | DRD2 (0.62) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9594314 | 0.84 | DRD2 (0.61) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7334500 | 0.83 | DRD2 (0.61) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9594433 | 0.83 | DRD2 (0.59) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7327870 | 0.82 | DRD2 (0.58) | DRD2DRD3DRD4HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |