Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330922 | 0.94 | ELANE (0.59) | ELANECCNA2CDK2CCNA1RAB9A | |
| Methyl Alcohol SCHEMBL7329268 | 0.79 | ELANE (0.52) | ELANEALDH1A1 | |
| SCHEMBL8866035 | 0.73 | ELANE (0.88) | ELANE | |
| SCHEMBL7305365 | 0.67 | ELANE (0.51) | ELANE | |
| SCHEMBL7337549 | 0.67 | ELANE (0.58) | ELANEALDH1A1 | |
| SCHEMBL2312705 | 0.65 | MMP8 (0.54) | ALDH1A1GAA | |
| SCHEMBL12951609 | 0.65 | MMP8 (0.54) | ALDH1A1GAA | |
| SCHEMBL4599256 | 0.65 | MMP8 (0.54) | ALDH1A1GAA | |
| SCHEMBL7305820 | 0.64 | ELANE (0.42) | ELANE | |
| SCHEMBL12987479 | 0.64 | KMT2A (0.47) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783589-A | 2-saccharinylmethyl aryl and arloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1998-07-21 | — | — | US | disclosed |
| US-5489604-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5385923-A | Treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |