Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508006 | 1.00 | TSHR (0.41) | TSHRCYP19A1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7331133 | 1.00 | TSHR (0.41) | TSHRCYP19A1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9182510 | 0.81 | TDP1 (0.35) | TSHRTDP1ALDH1A1SMN1; SMN2GLA | |
| SCHEMBL29826970 | 0.80 | TDP1 (0.45) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6480647 | 0.80 | TDP1 (0.45) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL27895212 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL27798784 | 0.78 | TDP1 (0.43) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A | |
| Methane SCHEMBL27917831 | 0.78 | TDP1 (0.43) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28454337 | 0.74 | TDP1 (0.41) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL30607492 | 0.74 | TDP1 (0.41) | TSHRTDP1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |