Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | STAT3 | P40763 | 1/20 | 0.63 |
| ▸ | STAT1 | P42224 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473565 | 0.86 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7326712 | 0.85 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7326994 | 0.85 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7336261 | 0.85 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL12685604 | 0.85 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL7326339 | 0.84 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL10472673 | 0.82 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL11705964 | 0.81 | NPC1 (0.44) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL11707726 | 0.81 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL11747150 | 0.81 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-5102890-A | Anxiolytic agents | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |
| US-4960779-A | Pyrrole derivatives, and pharmaceutical compositions which contain them and pharmacological methods of use | RHONE-POULENC SANTE (FR) | 1990-10-02 | — | — | US | disclosed |
| US-4898871-A | Pyrrole derivatives and pharmaceutical compositions which contain them as hypnotics and anticonvulsants | RHONE-POULENC SANTE (FR) | 1990-02-06 | — | — | US | disclosed |
| US-4038391-A | TRANQUILIZERS, ANTICONVULSANTS | RHONE-POULENC S.A. (FR) | 1977-07-26 | — | — | US | disclosed |
| US-4016274-A | TRANQUILIZERS AND ANTICONVULSANT AGENTS | RHONE-POULENC S.A. (FR) | 1977-04-05 | — | — | US | disclosed |