Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | FOS | P01100 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11051985 | 0.84 | LDHA (0.53) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL2564908 | 0.83 | LDHA (0.59) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL266195 | 0.83 | LDHA (0.59) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL3371646 | 0.83 | LDHA (0.59) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL31545634 | 0.83 | LDHA (0.59) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL31545527 | 0.83 | LDHA (0.59) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL7143727 | 0.81 | LDHA (0.57) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL5712536 | 0.81 | LDHA (0.57) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL14044083 | 0.81 | LDHA (0.57) | LDHACA2ATMKDM4EALOX15 | |
| SCHEMBL11419411 | 0.81 | LDHA (0.57) | LDHACA2ATMKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125053-B1 | PROCESS FOR PREPARING SECONDARY AMINES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-09-17 | — | — | EP | disclosed |
| US-4579972-A | Intermediates for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-01 | — | — | US | disclosed |
| US-4540819-A | Process for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0125053-A1 | Process for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |
| US-4359464-A | 3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof | SMITHKLINE BECKMAN CORPORATION (US) | 1982-11-16 | — | — | US | disclosed |
| US-4352754-A | HYPOTENSIVE, ANTI-PARKINSON | SMITHKLINE CORPORATION (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0004794-B1 | SUBSTITUTED BENZAZEPINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1982-04-28 | — | — | EP | disclosed |
| US-4321195-A | 6-Halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |
| US-4255422-A | DIURETICS, TREATMENT OF CARDIOVASCULAR DISORDERS | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4251525-A | FOR TREATING ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| EP-0022330-A2 | Synergistic antihypertensive compositions | SMITHKLINE BECKMAN CORPORATION (US) | 1981-01-14 | — | — | EP | disclosed |
| US-4197297-A | 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1980-04-08 | — | — | US | disclosed |
| US-4192872-A | ANTI -PARKINSONISM ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-03-11 | — | — | US | disclosed |
| EP-0004794-A2 | Substituted benzazepines, processes for preparing them and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-10-17 | — | — | EP | disclosed |
| US-4171359-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4160765-A | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds | SMITHKLINE CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
| US-4104379-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |