Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 4/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343087 | 0.94 | EEF2K (0.40) | ALDH1A1MAPTEEF2KMMP13SLC1A2 | |
| SCHEMBL8716303 | 0.91 | EEF2K (0.46) | ALDH1A1MAPTEEF2KMEN1KMT2A | |
| SCHEMBL7335977 | 0.90 | MMP13 (0.43) | MMP13F2 | |
| SCHEMBL7302360 | 0.86 | ACACB (0.45) | F10F2 | |
| SCHEMBL7332989 | 0.84 | F2 (0.47) | F10F2 | |
| SCHEMBL8721787 | 0.84 | EEF2K (0.46) | ALDH1A1MAPTEEF2KMMP13SLC1A2 | |
| SCHEMBL7332615 | 0.83 | F2 (0.49) | F10F2 | |
| SCHEMBL8719583 | 0.82 | F2 (0.48) | F10F2 | |
| SCHEMBL7338481 | 0.82 | F2 (0.43) | F10SLC1A2ITGB3ITGA2BF2 | |
| SCHEMBL7298351 | 0.80 | F2 (0.43) | ALDH1A1MAPTF10MMP13POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |