Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | PPIA | P62937 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 4/20 | 0.31 |
| ▸ | CCKAR | P32238 | 3/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331912 | 0.94 | PPIA (0.32) | SCN9APPIA | |
| SCHEMBL7324561 | 0.93 | SCN9A (0.32) | SCN9APPIACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7332332 | 0.93 | PPIA (0.32) | PPIA | |
| SCHEMBL7334581 | 0.92 | MDM2 (0.33) | PPIA | |
| SCHEMBL8842811 | 0.91 | SCN9A (0.33) | SCN9APPIACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7323957 | 0.88 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL7324067 | 0.87 | PPIA (0.31) | PPIA | |
| SCHEMBL8843425 | 0.86 | SCN9A (0.33) | SCN9APPIACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7335488 | 0.86 | — | — | |
| SCHEMBL7320615 | 0.85 | MDM2 (0.33) | PPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565449-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| US-5403836-A | Anticoagulants | GENENTECH, INC. (US) | 1995-04-04 | — | — | US | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5250679-A | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor | GENENTECH, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |