SCHEMBL7330397

SCHEMBL7330397

O=C1CNC(=O)N1CCCl

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
GSK3A P49840 1/20 0.50
GSK3B P49841 1/20 0.50
ALDH1A1 P00352 3/20 0.38
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
GAA P10253 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ABL1 P00519 1/20 0.35
LMNA P02545 1/20 0.35
RIN1 Q13671 1/20 0.35
POLB P06746 1/20 0.34
QPCT Q16769 1/20 0.33
KDM4E B2RXH2 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14761839 0.85 GSK3A (0.46) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL14233263 0.81
SCHEMBL839846 0.77 TSHR (0.50) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL853544 0.77 TSHR (0.50) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL10979078 0.77 TSHR (0.50) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL1969772 0.77 TSHR (0.55) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL10963438 0.77 TSHR (0.50) TSHRGSK3AGSK3BALDH1A1KMT2A
Hydrochloric Acid SCHEMBL2980753 0.76 TSHR (0.48) TSHRGSK3AGSK3BALDH1A1KMT2A
SCHEMBL7453981 0.74 TSHR (0.47) TSHRGSK3AGSK3BKMT2AMEN1
SCHEMBL9755587 0.74 TSHR (0.47) TSHRGSK3AGSK3BALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489341-B1 REDUCING OR AVOIDING ADVERSE EFFECTS ASSOCIATED WITH THE ADMINISTRATION OF SERTINDOLE, BY ADMINISTRATING A SERTINDOLE DERIVATIVE SUCH AS NOR-SERTINDOLE, 5-OXO-SERTINDOLE, DEHYDRO-SERTINDOLE OR DEHYDRO-NOR-SERTINDOLE SEPRACOR INC. 2002-12-03 US disclosed
EP-0726898-B1 PHENYLINDOLE COMPOUNDS LUNDBECK & CO AS H (DK) 2000-12-20 EP disclosed
WO-2000072837-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLEPTIC AND RELATED DISORDERS USING SERTINDOLE DERIVATIVES SEPRACOR INC. (US) 2000-12-07 WO disclosed
US-5703087-A PSYCHOLOGICAL DISORDERS H. LUNDBECK A/S (DK) 1997-12-30 US disclosed
EP-0726898-A1 PHENYLINDOLE COMPOUNDS H. LUNDBECK A/S (DK) 1996-08-21 EP disclosed
WO-1995012591-A1 PHENYLINDOLE COMPOUNDS H. LUNDBECK A/S (DK) 1995-05-11 WO disclosed
US-5075301-A FURAN DERIVATIVES USEFUL FOR THE TREATMENT OF GASTRO-INTESTINAL DISORDERS KYOWA HAKKO KOGYO, CO., LTD. (JP) 1991-12-24 US disclosed
EP-0413343-A2 Furan derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-02-20 EP disclosed
US-4105774-A CNS ANTITUMOR, INTRAPERITONEAL LEUKEMIA, MELANOMA, LEWIS LUNG CARCINOMA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF STATE (US) 1978-08-08 US disclosed