Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903450 | 0.78 | PDE4B (0.47) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL4901340 | 0.77 | HRH3 (0.47) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7327890 | 0.77 | PDE3B (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8191155 | 0.77 | PDE3B (0.61) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7337183 | 0.75 | PDE3B (0.49) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL4905175 | 0.74 | PDE3B (0.53) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20703292 | 0.74 | PDE3B (0.77) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7333837 | 0.71 | PDE3B (0.44) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL4892793 | 0.71 | PDE3B (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7328498 | 0.71 | PDE3B (0.51) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |