Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723247 | 0.88 | APP (0.42) | APPPDE5AKCNH2KDM4EALDH1A1 | |
| SCHEMBL23723285 | 0.83 | APP (0.43) | APPPDE5AKCNH2KDM4EALDH1A1 | |
| SCHEMBL31416041 | 0.75 | CACNA2D1 (0.40) | APPPDE5AKDM4EALDH1A1GBA1 | |
| SCHEMBL3113119 | 0.74 | MAOA (0.42) | APPPDE5AKCNH2KDM4EALDH1A1 | |
| SCHEMBL4031318 | 0.72 | KDM4E (0.49) | APPPDE5AKDM4EALDH1A1MAOA | |
| SCHEMBL3121144 | 0.72 | POLB (0.38) | APPPDE5AKCNH2KDM4EALDH1A1 | |
| SCHEMBL4089463 | 0.72 | METAP1 (0.40) | APPPDE5AKCNH2KDM4EALDH1A1 | |
| SCHEMBL3113231 | 0.72 | APP (0.41) | APPPOLBLMNAKMT2AMEN1 | |
| SCHEMBL3113186 | 0.72 | EGFR (0.49) | APPLMNAKMT2A | |
| SCHEMBL3106594 | 0.71 | MAPT (0.42) | APPPDE5AKDM4EALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |