Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cdp840. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.88 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.88 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.88 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cdp840 SCHEMBL7331058 | 1.00 | PDE4A (0.88) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL7332813 | 0.95 | PDE4A (0.83) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL153739 | 0.94 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL29351573 | 0.94 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL1389110 | 0.94 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL84490 | 0.94 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL29412448 | 0.94 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL16654879 | 0.93 | PDE4D (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL15264054 | 0.93 | PDE4D (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6251077 | 0.90 | PDE4A (0.92) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | claimed |
| WO-1995035282-A1 | (R)-4-(2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PHENYLETHYL) PYRIDINE HYDROGEN SULPHATE SALT AS PDE TYPE IV INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| WO-1995035282-A1 | (R)-4-(2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PHENYLETHYL) PYRIDINE HYDROGEN SULPHATE SALT AS PDE TYPE IV INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
| WO-1995035282-A1 | (R)-4-(2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PHENYLETHYL) PYRIDINE HYDROGEN SULPHATE SALT AS PDE TYPE IV INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
| WO-1995035282-A1 | (R)-4-(2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PHENYLETHYL) PYRIDINE HYDROGEN SULPHATE SALT AS PDE TYPE IV INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |