Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343150 | 0.92 | HTR1A (0.53) | HTR1ADRD3SIGMAR1KDM4ELMNA | |
| SCHEMBL7289555 | 0.88 | HTR1A (0.57) | HTR1ADRD3SIGMAR1DRD2DRD4 | |
| SCHEMBL7287704 | 0.88 | HTR1A (0.54) | HTR1ADRD3SIGMAR1KDM4ELMNA | |
| SCHEMBL7295734 | 0.87 | MAPT (0.52) | HTR1ADRD3SIGMAR1MAPT | |
| SCHEMBL7289185 | 0.85 | DRD3 (0.55) | HTR1ADRD3SIGMAR1KDM4EDRD2 | |
| SCHEMBL7298208 | 0.83 | DRD3 (0.49) | HTR1ADRD3SIGMAR1LMNAMAPT | |
| SCHEMBL7290257 | 0.82 | HTR1A (0.56) | HTR1ADRD3SIGMAR1KDM4EDRD2 | |
| SCHEMBL7298721 | 0.81 | HTR1A (0.56) | HTR1ADRD3SIGMAR1KDM4ELMNA | |
| SCHEMBL11827010 | 0.81 | HTR1A (0.53) | HTR1ADRD3SIGMAR1DRD2 | |
| SCHEMBL7295751 | 0.80 | HTR1A (0.57) | HTR1ADRD3SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436157-B1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-23 | — | — | EP | disclosed |
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5264438-A | Dopamine receptor agonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| CN-1053063-A | Quinazoline derivant and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-07-17 | — | — | CN | disclosed |
| EP-0436157-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-10 | — | — | EP | disclosed |