Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395909 | 0.91 | HRH3 (0.53) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7325184 | 0.86 | HRH3 (0.53) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7326514 | 0.85 | HRH3 (0.52) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7328015 | 0.85 | HRH3 (0.52) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7328115 | 0.85 | HRH3 (0.52) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10370841 | 0.84 | HRH3 (0.54) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7362081 | 0.82 | MAPT (0.51) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10369572 | 0.79 | HRH3 (0.59) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7335052 | 0.78 | HRH3 (0.57) | HRH3PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7327130 | 0.78 | HRH3 (0.60) | HRH3PDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |