Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325184 | 0.89 | HRH3 (0.53) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7328115 | 0.84 | HRH3 (0.52) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7328015 | 0.84 | HRH3 (0.52) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7326514 | 0.84 | HRH3 (0.52) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7332131 | 0.84 | HRH3 (0.48) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7327130 | 0.81 | HRH3 (0.60) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL10369572 | 0.80 | HRH3 (0.59) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7335052 | 0.80 | HRH3 (0.57) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL10560392 | 0.79 | PDE3B (0.61) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL9484349 | 0.77 | HRH3 (0.70) | HRH3PDE3BPDE3ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175363-B1 | 4,5-DIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1990-01-17 | — | — | EP | disclosed |
| US-4816454-A | CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-03-28 | — | — | US | disclosed |
| EP-0175363-A2 | 4,5-Dihydro-3(2H)-pyridazinones, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |