Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4A | P27815 | 8/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335795 | 1.00 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7328719 | 0.99 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7326412 | 0.90 | HDAC1 (0.58) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL5348988 | 0.84 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7332617 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL8157358 | 0.82 | HDAC1 (0.56) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7324348 | 0.82 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7335293 | 0.82 | PDE4A (0.58) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL7324583 | 0.81 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7324666 | 0.81 | RECQL (0.58) | PDE4BPDE4APDE4CPDE4DHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |