Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332908 | 0.85 | KDM4E (0.73) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7336879 | 0.84 | KDM4E (0.71) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7336472 | 0.81 | KDM4E (0.79) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL11701339 | 0.76 | DRD4 (0.77) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL8216991 | 0.76 | KDM4E (0.59) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7334661 | 0.75 | KDM4E (0.58) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7342750 | 0.75 | KDM4E (0.58) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7336105 | 0.74 | KDM4E (0.60) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7334310 | 0.72 | KDM4E (0.61) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7334407 | 0.72 | KDM4E (0.55) | KDM4EPOLBKCNH2HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922715-A | 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-07-13 | — | — | US | disclosed |