Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131134 | 0.89 | KDM4E (0.55) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7342750 | 0.88 | KDM4E (0.58) | KDM4EPOLBKCNH2KMT2AHTR1A | |
| SCHEMBL8216991 | 0.86 | KDM4E (0.59) | KDM4EPOLBKCNH2KMT2AHTR1A | |
| SCHEMBL7332908 | 0.86 | KDM4E (0.73) | KDM4EPOLBKCNH2KMT2AHTR1A | |
| SCHEMBL7334661 | 0.85 | KDM4E (0.58) | KDM4EPOLBKCNH2HTR1AADRA1D | |
| SCHEMBL7336472 | 0.83 | KDM4E (0.79) | KDM4EPOLBKCNH2KMT2AHTR1A | |
| SCHEMBL7335763 | 0.76 | KCNH2 (0.43) | KDM4EPOLBKCNH2KMT2AGAA | |
| SCHEMBL7335016 | 0.76 | POLB (0.48) | KDM4EPOLBKCNH2KMT2AHTR1A | |
| SCHEMBL11545921 | 0.75 | NPC1 (0.68) | KDM4EPOLBKCNH2KMT2ARAB9A | |
| SCHEMBL7339996 | 0.75 | ALDH1A1 (0.50) | KDM4EPOLBKCNH2KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0964854-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0964853-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| US-5972958-A | 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998035946-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035947-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |