Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SELP | P16109 | 2/20 | 0.42 |
| ▸ | SELL | P14151 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10620933 | 0.82 | ALDH1A1 (0.58) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL13715485 | 0.81 | KDM4E (0.58) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL13715472 | 0.81 | KDM4E (0.50) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL4826054 | 0.79 | ALDH1A1 (0.52) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL5682959 | 0.78 | KDM4E (0.47) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL6474760 | 0.78 | KDM4E (0.47) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL6290067 | 0.78 | ELANE (0.40) | KDM4EHSD17B10GRM1MAPTALDH1A1 | |
| SCHEMBL5875105 | 0.77 | KDM4E (0.50) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL8718307 | 0.77 | MAPT (0.55) | KDM4EHSD17B10MAPTPOLBNPC1 | |
| SCHEMBL2965923 | 0.77 | KDM4E (0.43) | KDM4EHSD17B10MAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127379-A | TREATING IRRITABLE BOWEL SYNDROME, URINARY INCONTINENCE, ATRIAL ARRHYTHMIA OR STROKE | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-10-03 | — | — | US | disclosed |
| US-5708174-A | Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-01-13 | — | — | US | disclosed |
| EP-0664805-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | disclosed |
| EP-0625149-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1994008994-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | disclosed |
| WO-1993016072-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-19 | — | — | WO | disclosed |