Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.93 |
| ▸ | HTR2A | P28223 | 5/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Blonanserin SCHEMBL119669 | 0.97 | DRD2 (1.00) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| Blonanserin SCHEMBL29379647 | 0.97 | DRD2 (1.00) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| SCHEMBL7334897 | 0.97 | DRD2 (1.00) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| Blonanserin SCHEMBL28204389 | 0.95 | DRD2 (0.98) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| Blonanserin SCHEMBL28331931 | 0.95 | DRD2 (0.98) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| SCHEMBL7326283 | 0.88 | DRD2 (0.84) | DRD2HTR2ACYP1A2CYP3A4POLB | |
| SCHEMBL9788695 | 0.87 | HTR2A (0.72) | DRD2HTR2ACYP1A2CYP3A4KDM4E | |
| SCHEMBL7328947 | 0.87 | HTR2A (0.71) | DRD2HTR2ACYP1A2CYP3A4HRH4 | |
| SCHEMBL7331312 | 0.86 | DRD2 (0.71) | DRD2HTR2ACYP1A2CYP3A4POLB | |
| SCHEMBL7325078 | 0.86 | HTR2A (0.80) | DRD2HTR2ACYP1A2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-B1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5021421-A | Psychotropic agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0385237-A2 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |